Gains of COL1A1-PDGFB genomic copies occur in fibrosarcomatous transformation of dermatofibrosarcoma protuberans
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چکیده
منابع مشابه
Dermatofibrosarcoma protuberans with fibrosarcomatous transformation*
To the Editor, Dermatofibrosarcoma protuberans (DFSP) is an uncommon sarcoma of the skin and soft tissue with an intermediate level of malignancy. DFSP with fibrosarcomatous differentiation (FS-DFSP) is a rare variant of DFSP, involving greater aggression, higher rates of local recurrences and a higher metastatic potential. We describe the case of a 70-year-old woman who presented with a painle...
متن کاملCongenital atrophic dermatofibrosarcoma protuberans detected by COL1A1-PDGFB rearrangement
BACKGROUND Atrophic variant of dermatofibrosarcoma protuberans (DFSP) is a distinct form of DFSP. CASE PRESENTATION Here, we report the case of a 19-year-old woman with a small congenital atrophic plaque on the right precordium. The lesion remained atrophic for more than 10 years. Several years earlier, a portion of the plaque became tuberous and enlarged. Physical examination revealed a 25 ×...
متن کاملDermatofibrosarcoma protuberans with fibrosarcomatous transformation of the head and neck
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Mediterranean female presented with a 45-day history of rapidly growing cutaneous lesion of the face. Surgical biopsy confirmed the diagnosis of DFSP. Subsequently, the patient underwent wide lo...
متن کاملAtrophic dermatofibrosarcoma protuberans: report of a case demonstrated by detecting COL1A1-PDGFB rearrangement
UNLABELLED Dermatofibrosarcoma protuberans is a locally aggressive mesenchymal neoplasm. It usually presents as an indurated plaque that protrudes above the surface of the skin. Some patients have clinically persistent plaques that might be atrophic. The atrophic variant of dermatofibrosarcoma protuberans may be confused with some common skin diseases with atrophic appearance. We reported a 40-...
متن کاملA Fibrosarcomatous ("High-Grade") Variant of Dermatofibrosarcoma Protuberans (DFSP)
Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon soft tissue tumor with intermediate-to-low grade malignancy. There is usually little nuclear pleomorfism and only low to moderate mitotic activity. Conventional DFSP, usually have fewer than 5 mitotic figures/10 high-power fields. We describe a case of a 74year old male patient who presented to the surgical clinic with active bleed...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2006
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.3800695